Isopsoralen; Angelicin

仅用于工业应用或科学研究，不可用于人类或动物的临床诊断或治疗，非药用.Angelicin, a furocoumarin naturally occurring tricyclic aromatic compound, structurally related to psoralens, is reported to have anti-cancer, antiviral, anti-inflammatory activity. IC50 value: 49.56 μM （cellular cytotoxicity）; 5.39 μg/ml （28.95 μM） （against MHV-68） Target: In vitro: In human SH-SY5Y neuroblastoma cells, angelicin increased cellular cytotoxicity in a dose- and time-dependent manner with IC50 of 49.56 μM at 48 h of incubation. Angelicin dose-dependently downregulated the expression of anti-apoptotic proteins including Bcl-2, Bcl-xL, and Mcl-1; Angelicin-induced apoptosis is mediated primarily through the intrinsic caspase-mediated pathway[1]. Angelicin efficiently inhibited 12-O-tetradecanoylphorbol-13-acetate （TPA）-induced lytic replication of human gammaherpresviruses in both EBV- and KSHV-infected cells